英國應(yīng)用光物理公司Applied?Photophysics?Ltd----世界知名的專業(yè)分析儀器制造商,所生產(chǎn)的圓二色光譜(CD)儀、停流stopped?flow?反應(yīng)動力學(xué)分析儀、激光閃解Laser?Flash?Photolysis?分析儀廣泛應(yīng)用于生命科學(xué)、化學(xué)、藥物學(xué)、材料學(xué)、環(huán)境科學(xué)等領(lǐng)域的分子結(jié)構(gòu)、分子間相互作用、動力學(xué)分析等領(lǐng)域的研究,特別是生物大分子、生物大分子與小分子如藥物、各類手性化合物等的結(jié)構(gòu)與相互作用的研究,在藥物研發(fā)、藥物篩選等基礎(chǔ)應(yīng)用研究上是常用的基本的研究工具,?知名制藥公司如GSK,?阿斯利康、諾和諾德、禮萊、羅氏,Amgen、Biogen等均有多臺本系列儀器在各個研究組發(fā)揮著重要的作用。
英國?Applied?Photophysics?Ltd?(?應(yīng)用光物理公司)?生產(chǎn)的?圓二色CD(circular?dichroism)?光譜儀、停流stopped?flow?反應(yīng)動力學(xué)分析儀、激光閃解Laser?Flash?Photolysis?分析儀,在國內(nèi)的清華大學(xué)、北京大學(xué)、復(fù)旦大學(xué)、武漢大學(xué)、中山大學(xué)?、山東大學(xué)的相應(yīng)學(xué)科的著名實驗室及中國科學(xué)院的相關(guān)院所有有很好的應(yīng)用,并有很好的高等級的文獻(xiàn)引用和發(fā)表。
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Applied?Photophysics?is?a?world-leading?manufacturer?and?supplier?of?precision?spectrometers?for?the?study?of?circular?dichroism,?stopped-flow?kinetics?and?laser?flash?photolysis.
The?company?supplies?the?life-sciences?community?in?both?academic?and?commercial?spheres?with?instruments?that?are?used?to?study?the?structural,?thermodynamic?and?kinetic?properties?in?solution?of?a?wide?range?of?samples.?The?current?main?product?range?comprises?the?Chirascan?circular?dichroism?spectrometer,?the?SX20?stopped-flow?spectrometer?and?the?LKS.60?laser?flash?photolysis?spectrometer.
The?products?from?Applied?Photophysics?are?designed?to?study?a?wide?range?of?molecules?and?are?widely?used?in?research?and?pharmaceutical?applications.?The?product?portfolio?includes?three?main?technology?platforms:
Circular?Dichroism?(CD)?spectroscopy?that?is?used?primarily?for?looking?at?protein?secondary?&?tertiary?structure,?protein?folding?and?the?stability?of?proteins?in?different?environments;?this?has?been?widely?adopted?in?many?applications?in?the?fields?of?biophysical?and?biochemistry?research.?Circular?dichroism?is?also?widely?used?in?the?Pharmaceutical?industry?particularly?in?biotherapeutic?drug?development?to?optimize?formulations?and?understand?protein?structure?and?stability.?Additionally?the?technique?has?also?been?used?in?pharmacokinetics?to?study?in-vitro?the?potential?interactions?of?small?molecule?drugs.
Applied?Photophysics?Chirascan?is?the?most?advanced?circular?dichroism?spectrometer?available?today.?It?is?particularly?valuable?in?elucidating?the?higher?structures?of?bio-macromolecules?in?solution,?for?example?the?secondary?structures?of?proteins,?DNA?and?RNA,?and?how?these?structures?change?when?stressed?by?temperature,?pH?or?other?means?such?as?drug?binding.
Stopped?flow?technology?is?extensively?used?to?study?biomolecular?interactions,?kinetics?and?fast?reaction?mechanisms?typical?of?many?reactions?in?chemical?and?biological?systems.?This?technology?has?been?widely?adopted?and?is?a?powerful?tool?for?analysis?of?mechanisms?of?a?great?variety?of?chemical?and?biochemical?phenomena.
Laser?flash?technology?is?used?to?measure?extremely?fast?reaction?mechanisms,?typically?of?transient?species?such?as?radicals,?excited?states?or?ions.?This?highly?specialised?technique?allows?probing?of?some?of?the?fastest?chemical?processes,?and?consequently?has?been?used?extensively?to?research?these?phenomena.
Applied?Photophysics?Limited?was?established?in?1971?by?The?Royal?Institution?of?Great?Britain.
For?more?information,?please?visit?http://www.photophysics.com/?.